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114977-28-5 Taxane Chemotherapy Drugs Docetaxel Intermediate USP38

114977-28-5 Taxane Chemotherapy Drugs Docetaxel Intermediate USP38

  • High Light

    taxane chemo

    ,

    taxane chemotherapy for breast cancer

  • Color
    White Or Off White
  • Appearance
    Crystal Powder
  • Standard
    USP38
  • M.F
    C43H53NO14
  • CAS No.
    14977-28-5
  • UN Number
    1544
  • HS Code
    2932999099
  • Other Name
    APV
  • Place of Origin
    Henan Province, China
  • Brand Name
    U-CHOICE
  • Certification
    ISO 9001 : 2008
  • Model Number
    USP38
  • Minimum Order Quantity
    500g
  • Price
    Negotiate
  • Packaging Details
    as demand
  • Delivery Time
    3-5 working days
  • Payment Terms
    T/T,
  • Supply Ability
    500 Kgs Per Month

114977-28-5 Taxane Chemotherapy Drugs Docetaxel Intermediate USP38

CAS No. 114977-28-5 Taxane Drugs Docetaxel USP38 White or off white crystalline powder​

 

 

Docetaxel (trade name Taxotere) is a clinically well established anti-mitotic chemotherapy medication (that is, it interferes with cell division).

 

1. It is a clinically well established anti-mitotic chemotherapy medication (that is, it interferes with cell division).
2. It is used mainly for the treatment of breast, ovarian, and non-small cell lung cancer.
3. It has an FDA approved claim for treatment of patients who have locally advanced, or metastatic breast or non small-cell lung cancer who have undergone anthracycline based chemotherapy and failed to stop cancer progression or relapsed. An European approval docetaxel for use in hormone-refractory prostate cancer.
4. It is considered better than doxorubicin, paclitaxel and fluorouracil as a cytotoxic antimicrotubule.

 
Technical Information
Technical Item Technical Data

Density

1.4±0.1 g/cm3

Boiling Point

900.5±65.0 ℃ at 760 mmHg

Molecular Formula

C43H53NO14

Molecular  Weight

807.879

Flash Point

498.4±34.3 

Exact Mass

807.346619

PSA

224.45000

Log P

6.55

Vapour Pressure

0.0± 0.3 mmHg at 25℃

Refractive Index

1.618

 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Function:
Docetaxel is used mainly for the treatment of breast, ovarian, and non-small cell lung cancer.

Docetaxel has an FDA approved claim for treatment of patients who have locally advanced, or metastatic breast or non small-cell lung cancer who have undergone anthracycline-based chemotherapy and failed to stop cancer progression or relapsed. An European approval docetaxel for use in hormone-refractory prostate cancer. Docetaxel is considered better than doxorubicin, paclitaxel and fluorouracil as a cytotoxic antimicrotubule.

 

Application:
Docetaxel intermediate is a crucial intermediate for Docitaxel, two of the best anti-cancer drugs ever invented. By extracting the pre-cursor, docetaxel intermediate in large quantites from the Taxus baccata leaf, many subsequent semi-syntheses can be carried out.
The esterification of docetaxel intermediate also causes an enhancement in the kinetics, and therefore the pharmacological profile of these important chemo-therapeutic agents.